The Research

Optimising outcomes for pregnant women with epilepsy & their children

This 5-year research programme dives deep into challenges faced by pregnant women with epilepsy. It seeks to shed light on things that matter to them, and will offer evidence based information and care pathway options that can be integrated into our health systems. It is made up the 'EpiSafe' study (focusing on pregnant women) and the 'EpiFollow' study (focusing on following up children of mothers with epilepsy).

Improving the lives of pregnant women with epilepsy

Epilepsy in Pregnancy: Disproportionately associated with adverse outcomes

In the UK, epilepsy affects 0.4% of women giving birth but accounts for 10% of maternal deaths.

The number of epilepsy-related maternal deaths has risen significantly, and neurological conditions are now the second highest cause of maternal deaths.

Seizures in Pregnancy:
Impact and risk factors

Seizures can worsen during pregnancy, affecting both mothers and babies, and increasing the risk of Sudden Unexpected Death in Epilepsy (SUDEP), accidents, and trauma.

Various factors influence seizure risks, including adherence to epilepsy medication and seizure control.

Anti-Epileptic Drug (AED)
use in Pregnancy

80% of pregnant women with epilepsy need AEDs, and in-utero exposure has been associated with congenital malformations and long-term neurodevelopmental issues.

Concerns about medication safety and limited information on long-term AED safety have eroded trust. Non-adherence can worsen seizure control, leading to serious complications.

Sereena